INTERRELATIONSHIP BETWEEN p-AMINOBENZOIC ACID AND PTEROYLGLUTAMIC ACID AS GROWTH FACTORS FOR LACTOBACILLI

INTERRELATIONSHIP BETWEEN p-AMINOBENZOIC ACID AND PTEROYLGLUTAMIC ACID AS GROWTH FACTORS FOR LACTOBACILLI*

The elucidation of the structure of pteroylglutamic acid (PGA) (Lactobacillus casei factor, vitamin B,) has shown that p-aminobenzoic acid (PABA) is a component of the PGA molecule (1). Since earlier work has treated PABA and PGA as distinct growth factors for bacteria (2), it is now necessary to study the relationship in the utilization of these substances by bacteria. It has been shown that m...

Separation of p-Aminobenzoic Acid Derivatives

According to the literature, p-aminobenzoic acid (PAB) is excreted in the urine mostly as the free acid and its N-acetyl derivative; the remaining part is eliminated conjugated with glucuronic acid and as p-aminohippuric acid (PAH) (Ellinger & Hensel, 1914'; Hensel, 1914; Cohen & McGilvery, 1946; Salassa, Bollman & Dry, 1948). There is no agreement concerning the formation of PAH. Thus, Beyer, ...

Pteroylglutamic Acid Malabsorption in

Pteroylglutamic acid (PGA) absorption days. A statistically significant difference was assessed in ten untreated tropical in PGA absorption between TS and consprue (TS) and eight control subjects trol subjects was obtained only when gluutilizing a marker perfusion technique. cose was present in the perfusate. Thus, Physiologic concentrations of the vitamin unequivocal malabsorption of PGA is (2...

A MICROBIOLOGICAL ASSAY METHOD FOR p-AMINOBENZOIC ACID

Since the eshablishment of p-aminobenzoic acid as a member of the B vitamin group, a considerable interest has been shown in methods of determination in natural materials. Since known chemical methods are not sufficiently sensitive, it became evident that microbiological tests should be the most practicable. The organism Clostridium acetobutylicum has been used (I) but no general assay procedur...

Pteroylglutamic acid and related compounds.